Autonomous strategies for the production of argumentative texts in the Peruvian jungle

The objective of this research was to analyze the autonomous strategies for the production of argumentative texts used by elementary school students from an educational institution in the Peruvian jungle, according to the subcategories metacognitive strategies and self-regulation strategies. The methodology is of qualitative approach, with the hermeneutic work method. The informants were 14 students. The technique was the interview where an unstructured interview guide was applied. The results show that most of the students used autonomous strategies for the production of argumentative texts, being the most prevalent those of organization and planning, information search via the Internet, underlining and summarizing. Conclusions: the autonomous strategies for the production of argumentative texts used by primary school students of an educational institution in the Peruvian jungle are in the categories of meta-cognition and self-regulation

Structural and functional interaction between polyamine related molecules and biological membranes

La comunicación describe el conocimiento actual sobre las interacciones de biomoléculas relacionadas con el metabolismo de poliaminas con las estructuras y funciones de las membranas biológicasChanges induced by PA on nucleic acid (NA) conformation and synthesis is proven to be a major reason for PA essentiality (1-3). However, PA interactions with other polyanions, for instance polyanionic membrane lipid bilayers and glyosaminoglycans have received less attention (3-4). The functional importance of these interactions still is an obscure but interesting area of cell and molecular biology, especially in mammalian cells for which specific PA transport systems are not fully characterized (5). In mammals, activity and turnover of the polyamine (PA) synthesis key enzyme is controlled by a set of proteins: Antizymes (OAZ1-3) and antizyme inhibitors (AZIN1 and 2). It is demonstrated that AOZ modulate polyamine uptake (6), and that PA transport to mitochondria is linked to the respiratory chain state and modulates mitochondrial permeability transition (7). Antizyme expression variants have been located in mitochondria, being proposed as a proapoptotic factor (7-8). AZIN 2 is only expressed in a reduced set of tissues that includes mast cells, where it is associated to mast cell granules membrane (9). This fact, together to the abnormalities observed in bone marrow derived mast cell granules when they are differentiated under restricted PA synthesis conditions (10 and unpublished results), point out to important roles of PA and their related proteins in structure and function of mast cell granules. We will also present novel biophysical results on tripartite interactions of PA that remark the interest of the characterization of PA interactions with lipid bilayers for biomedicine and biotechnology. Thus, the information reported in this paper integrates previously reported information with our still unpublished results, all indicating that PA and their related proteins also are important factors for structure and dynamics of biological membranes and their associated functions essential in human physiology; for instance, solute interchange with the environment (uptake and secretion), oxidative metabolism and apoptosis. The importance of these involved processes for human homeostasis claim for further research efforts. 1. Ruiz-Chica J, Medina MA, Sánchez-Jiménez F and Ramírez FJ (2001) Fourier Transform Raman study of the structural specificities on the interaction between DNA and biogenic polyamines. Biophysical J. 80:443-454. 2. Lightfoot HL, Hall J (2014) Endogenous polyamine function--the RNA perspective. Nucleic Acids Res. 42:11275-11290. 3. Igarashi K, Kashiwagi K (2010) Modulation of cellular function by polyamines. Int J Biochem Cell Biol. 42:39-51. 4. Finger S, Schwieger C, Arouri A, Kerth A, Blume A (2014) Interaction of linear polyamines with negatively charged phospholipids: the effect of polyamine charge distance. Biol Chem. 395:769-778. 5. Poulin R, Casero RA, Soulet D. (2012) Recent advances in the molecular biology of metazoan polyamine transport. Amino Acids. 42:711-723. 6. Kahana C (2009) Regulation of cellular polyamine levels and cellular proliferation by antizyme and antizyme inhibitor. Essays Biochem. 4:47-61. 7. Agostinelli E, Marques MP, Calheiros R, Gil FP, Tempera G, Viceconte N, Battaglia V, Grancara S, Toninello A (2010) Polyamines: fundamental characters in chemistry and biology. Amino Acids 38:393-403. 8. Liu GY, Liao YF, Hsu PC, Chang WH, Hsieh MC, Lin CY, Hour TC, Kao MC, Tsay GJ, Hung HC (2006) Antizyme, a natural ornithine decarboxylase inhibitor, induces apoptosis of haematopoietic cells through mitochondrial membrane depolarization and caspases' cascade. Apoptosis 11:1773-1788. 9. Kanerva K, Lappalainen J, Mäkitie LT, Virolainen S, Kovanen PT, Andersson LC (2009). Expression of antizyme inhibitor 2 in mast cells and role of polyamines as selective regulators of serotonin secretion. PLoS One 31:e6858. 10. García-Faroldi G, Rodríguez CE, Urdiales JL, Pérez-Pomares JM, Dávila JC, Pejler G, Sánchez-Jiménez F, Fajardo I (2010) Polyamines are present in mast cell secretory granules and are important for granule homeostasis. PLoS One 30:e15071.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

La Satisfacción del cliente con el Supermercadismo en áreas de frontera

Supermarkets face difficulty situations where they have to grow, expand and stay in the market. In this scenario, the efforts of the various selling strategies can provide effective and efficient differentials, contributing greatly to the survival of organizations. This article aims to identify the consumer profile, analyze consumer relationships with supermarkets and also detecting the level of consumer satisfaction with supermarkets in the city of Paso de los Libres, Argentinean – Brazilian border. Also, make an exploratory, qualitative and quantitative study, with 03 supermarkets. The sample population consists of 200 consumers surveyed, with 100 Argentine and 100 Brazilian pepople. It is a random sample, the result of research done in the first half of July 2014. The results are a collection of data and information for the selection of the strategic actions for sale, but also allows a comparison between the two samples. Between Brazilian and Argentinean people, you can compare some resultsto identify some market related and cultural differences, and identify the degree of satisfaction of both nationalities investigated. Los supermercados enfrentan situaciones difíciles en las que tienen que crecer, expandirse y mantenerse en el mercado. En este escenario, los esfuerzos a las diversas estrategias de venta pueden proporcionar diferenciales eficaces y eficientes, contribuyendo en gran medida a la supervivencia de las organizaciones. Este articulo tiene como objetivos identificar el perfil del consumidor, analizar las relaciones de consumo con los supermercados y también detectar el nivel de satisfacción de los consumidores con los supermercados en la ciudad de Paso de los Libres, frontera Argentina – Brasil. Además, llevar a cabo un estudio exploratorio, cualitativo y cuantitativo, con tres supermercados. La población de la muestra está compuesta por 200 consumidores encuestados, siendo 100 argentinos y 100 brasileros. Es una muestra aleatoria, fruto de una investigación hecha en la primera quincena de julio 2014. Los resultados constituyen una colección de datos e información para la selección de las acciones estratégicas para la venta, pero también permiten realizar una comparación entre las dos muestras. Entre brasileros y argentinos, se puede comparar algunos resultados buscando identificar diferencias mercadológicas y culturales, además de identificar el grado de satisfacción de ambas nacionalidades investigadas

ANÁLISIS DEL MERCADO DE TRABAJO RURAL EN LA REGIÓN TUMBES. CASO ESTUDIO: PAPAYAL./MARKET ANALYSIS OF RURAL WORK IN TUMBES. CASE STUDY: PAPAYAL

RESUMEN El presente trabajo de investigación, se desarrolló en el ámbito rural, en la localidad de Papayal, provincia de Zarumilla, Región Tumbes, con el propósito de analizar el mercado de trabajo a partir de la relación entre ingresos laborales, la baja productividad y cómo influye la dimensión social. Para las acciones del proyecto se efectuó un diagnóstico, se validó información de pobladores rurales, municipio, gobernación, Instituto Nacional de Estadística e Informática - INEI; para la recolección de datos de campo, se efectuaron encuestas a pobladores rurales del distrito, asimismo entrevistas a pobladores, autoridades y organizaciones de la sociedad civil; tomándose en cuenta el funcionamiento de las instituciones del mercado de trabajo, los procesos laborales y la dinámica del desempleo. Se determinó que las unidades productivas son de menor tamaño, 1 hectárea en promedio, esta restricción constituye una limitación importante para los hogares rurales; se constató la presencia de un determinado número de productores capaces de satisfacer requerimientos laborales con mano de obra familiar y sus requerimientos de capital con medios de producción propios; en consecuencia, el escaso desarrollo del mercado de trabajo rural, se debe a la necesidad de obtener mayores ingresos en actividades no agropecuarias y también a restricciones presentes en el mercado de crédito. ABSTRACT This investigation work was developed in rural areas, in the locality of Papayal, province of Zarumilla, Tumbes Region, in order to analyze the labor market from the relationship between labor income and the low productivity and how it influences the social dimension. For the project actions, diagnosis was made, It was validated the   information of rural people, Municipality, Government, National Institute of Statistics and Information from – INEI.  In order to get a data collection of the field,  we conducted some survey  to rural residents of the district and also interviews with residents, authorities and civil society organizations, taking into account the functioning of market institutions, the labor processes and the unemployment dynamics,It was determined that the production units are smaller, 1 hectare on average, this restriction is a major limitation for rural households, it was found the presence of a determined number of producers capable of satisfying labor requirements with family labor and their capital requirements with own production means, in consequence, the poor development of the rural labor market is due to the need to earn more incomes in non-agricultural activities and also to restrictions contained in the credit market

Photon-number-resolving segmented avalanche-photodiode detectors

We investigate the feasibility and performance of photon-number-resolved photodetection employing avalanche photodiodes (APDs) with low dark counts. The main idea is to split n photons over m modes such that every mode has no more than one photon, which is detected alongside propagation by an APD. We characterize performance by evaluating the purities of positive-operator-valued measurements (POVMs), in terms of APD number and photon loss.Comment: 5 pages, 7 figures, submitted for publicatio

DISEÑO DE UNA MÁQUINA SECADORA DE GRANOS DE ARROZ PORTÁTIL CON CAPACIDAD DE SILO DE 7M3 PARA LOS PEQUEÑOS PRODUCTORES ARROCEROS DE LA REGION LAMBAYEQUE-PERÚ

En el presente proyecto de investigación contempla el diseño de una máquina portátil del secado de grano de arroz, orientado en las necesidades del pequeño productor de arroz de la región Lambayeque y así incrementar el valor de su producción, con la optimización el secado tradicional en su proceso, obteniendo la humedad en un valor adecuado en el menor tiempo, mediante teorías científicas de diseño mecánico aplicando cálculo analítico, así mismo se realizará la simulación, diseño y ajustes de parámetros en SOLIDWORKS software de ingeniería. Además, el presente diseño busca optimizar recurso y economía haciendo que la máquina sea portátil utilizando como combustible la cascarilla de arroz con capacidad de silo de 7m3, en un sistema compacto de remolque, la cual soportará diferentes componentes del trabajo integrados los que brindaran los beneficios de una secadora industrial de arroz, considerando las normativas vehiculares vigentes, las que influencian en la optimización

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

Several pathological processes, such as sepsis and inflammatory bowel disease (IBD), are associated with impairment of intestinal epithelial barrier. Here, we investigated the role of matrix metalloproteinase MMP13 in these diseases. We observed that MMP13(-/-) mice display a strong protection in LPS- and caecal ligation and puncture-induced sepsis. We could attribute this protection to reduced LPS-induced goblet cell depletion, endoplasmic reticulum stress, permeability and tight junction destabilization in the gut of MMP13(-/-) mice compared to MMP13(+/+) mice. Both in vitro and in vivo, we found that MMP13 is able to cleave pro-TNF into bioactive TNF. By LC-MS/MS, we identified three MMP13 cleavage sites, which proves that MMP13 is an alternative TNF sheddase next to the TNF converting enzyme TACE. Similarly, we found that the same mechanism was responsible for the observed protection of the MMP13(-/-) mice in a mouse model of DSS-induced colitis. We identified MMP13 as an important mediator in sepsis and IBD via the shedding of TNF. Hence, we propose MMP13 as a novel drug target for diseases in which damage to the gut is essential

Long-term results between interval surgery and follow-up after percutaneous cholecystostomy: a retrospective cohort study

Introduction: Although cholecystectomy is the treatment of choice for acute cholecystitis (AC), in patients with high surgical risk percutaneous cholecystostomy (PC) is chosen in some cases. The aim of this report is to follow up these patients and evaluate biliary recurrences after PC. Methods: A descriptive retrospective study was carried out in a third level hospital from August 2005 to December 2014. All patients diagnosed with acute lithiasis cholecystitis who were indicated as initial treatment with antibiotic therapy and PC echo-guided were included. Patients requiring emergent cholecystectomy during hospital and those who died during the AC episode were excluded. After hospital discharge, the patients were divided into two groups group 1 (interval cholecystectomy) and group 2 (no surgery). Results: From the 86 healed patients, there were 8 losses in the follow-up, so 78 patients were analyzed group 1 (n = 12) and group 2 (n = 66

A high-fat meal impairs muscle vasodilatation response to mental stress in humans with Glu27 β2-adrenoceptor polymorphism

<p>Abstract</p> <p>Background</p> <p>Forearm blood flow responses during mental stress are greater in individuals homozygous for the Glu27 allele. A high-fat meal is associated with impaired endothelium-dependent dilatation. We investigated the impact of high-fat ingestion on the muscle vasodilatory responses during mental stress in individuals with the Glu27 allele and those with the Gln27 allele of the β₂-adrenoceptor gene.</p> <p>Methods</p> <p>A total of 162 preselected individuals were genotyped for the Glu27Gln β₂-adrenoceptor polymorphism. Twenty-four individuals participated in the study. Fourteen were homozygous for the Gln27 allele (Gln27Gln, 40 ± 2 years; 64 ± 2 kg), and 10 were homozygous for the Glu27 allele (Glu27Glu, 40 ± 3 years; 65 ± 3 kg). Forearm blood flow was evaluated by venous occlusion plethysmography before and after ingestion of 62 g of fat.</p> <p>Results</p> <p>The high-fat meal caused no changes in baseline forearm vascular conductance (FVC, 2.2 ± 0.1 vs. 2.4 ± 0.2; <it>P </it>= 0.27, respectively), but reduced FVC responses to mental stress (1.5 ± 0.2 vs. 0.8 ± 0.2 units; <it>P </it>= 0.04). When volunteers were divided according to their genotypes, baseline FVC was not different between groups (Glu27Glu = 2.4 ± 0.1 vs. Gln27Gln = 2.1 ± 0.1 units; <it>P </it>= 0.08), but it was significantly greater in Glu27Glu individuals during mental stress (1.9 ± 0.4 vs. 1.0 ± 0.3 units; <it>P </it>= 0.04). High-fat intake eliminated the difference in FVC responses between Glu27Glu and Gln27Gln individuals (FVC, 1.3 ± 0.4 vs. 1.2 ± 0.4; <it>P </it>= 0.66, respectively).</p> <p>Conclusion</p> <p>These findings demonstrate that a high-fat meal impairs muscle vasodilatation responses to mental stress in humans. However, this reduction can be attributed to the presence of the homozygous Glu27 allele of the β₂-adrenoceptor gene.</p

Holographic Josephson Junctions and Berry holonomy from D-branes

We construct a holographic model for Josephson junctions with a defect system of a Dp brane intersecting a D(p+2) brane. In addition to providing a geometrical picture for the holographic dual, this leads us very naturally to suggest the possibility of non-Abelian Josephson junctions characterized in terms of the topological properties of the branes. The difference between the locations of the endpoints of the Dp brane on either side of the defect translates into the phase difference of the condensate in the Josephson junction. We also add a magnetic flux on the D(p+2) brane and allow it evolve adiabatically along a closed curve in the space of the magnetic flux, while generating a non-trivial Berry holonomy.Comment: 20 pages, 2 figure